研究生教育是培养高素质人才和创新能力的关键环节,在当前教育改革的大背景下,我们积极践行“以学生为中心”的教学理念,致力于构建符合学生需求和发展规律的研究生系统生物学和生物信息学课程体系,通过实施教学内容模块化、整合优质在线资源、思政教育融入、采用多种教学方法和教学手段、构建多元化评价体系以及加强师资队伍建设等一系列改革措施,增强课程的系统性与实践性,为相关课程的建设和改革提供参考。Graduate education plays a crucial role in nurturing high-quality talent and fostering innovative capabilities. We actively implement a “student-centered” teaching philosophy aimed at developing a curriculum in graduate Systems Biomedicine and Bioinformatics that aligns with students’ needs and developmental principles. This paper focuses on the construction and reform of graduate courses in Systems Biomedicine and Bioinformatics. It outlines a series of reform measures that include the implementation of modular teaching content, the integration of high-quality online resources, the incorporation of ideological and political education, and the adoption of diverse teaching methods and strategies. Additionally, it emphasizes the establishment of a comprehensive evaluation system and the strengthening of faculty expertise. Through these initiatives, the approach aims to enhance the systematic and practical aspects of the courses, ultimately providing valuable insights for the development and reform of related curricula.