目的总结系统性红斑狼疮患者运动干预的最佳证据。方法采用澳大利亚乔安娜布里格斯研究所循证卫生保健中心的"PIPOST"模式构建循证护理问题,根据"6S"证据资源金字塔模型自上至下检索BMJ Best Practice、UpToDate、指南网站、专业协会网站及国内外中英文数据库中有关系统性红斑狼疮患者运动干预的临床指南、共识、系统评价、最佳实践、证据总结等相关证据。筛选符合质量标准的文献进行质量评价,提取证据。检索时限为建库至2024年6月15日。结果共纳入15篇文献,其中临床决策1篇,指南3篇,系统评价6篇,随机对照试验5篇。从运动原则、运动评估、运动方式、运动强度、运动频率和时间、运动监测6个方面汇总形成了25条证据。结论本研究汇总的系统性红斑狼疮患者运动干预的最佳证据,可为临床医务人员提供参考依据。
目的:为探究外周血Zonulin在评估系统性红斑狼疮(SLE)患者肠道通透性、疾病活动度以及受累脏器的临床价值。方法:共纳入60名SLE女性患者,通过ELISA测量血清连蛋白(Zonulin)及脂肪酸结合蛋白(IFABP)水平,并收集系统性红斑狼疮疾病活动指数(SLEDAI-2k)评分及临床指标评估疾病活动度,通过线性回归和Pearson相关性评估外周血Zonulin、IFABP水平与SLEDAI-2k及临床指标之间的相关性。结果:SLE患者中外周血Zonulin (p p p p 2 = 0.5247, p p p Objective: To explore the clinical value of peripheral blood Zonulin in the evaluation of intestinal permeability, disease activity, and affected organs in patients with systemic lupus erythematosus (SLE). Methods: 60 female patients with SLE were enrolled. Serum levels of Zonulin and intestinal fatty acid-binding protein (IFABP) were measured by ELISA. The SLE Disease Activity Index (SLEDAI-2k) score and clinical indicators were collected to assess disease activity. Linear regression and Pearson correlation were used to evaluate the correlations between Zonulin, IFABP in peripheral blood and SLEDAI-2k, clinical indicators. Results: Compared to healthy controls, the levels of Zonulin (p p p p 2 = 0.5247, p p p < 0.001) was negatively correlated. However, there was no statistically significant difference in Zonulin and IFABP levels in peripheral blood among patients with different organ involvements. Conclusion: Zonulin in peripheral blood may be associated with disease activity and exacerbation, potentially serving as a biomarker for the severity and progression of SLE, but it is unrelated to the involved organs and systems.