目的:探讨预后营养指数(prognostic nutritional index, PNI)与溃疡性结肠炎(ulcerative colitis, UC)患者疾病活动度的相关性。方法:回顾性分析2016年9月至2024年5月期间于河北省人民医院首次明确诊断为UC的患者117例。收集患者的基本信息、临床症状、实验室检查及内镜检查等结果。根据改良Mayo评分系统评估患者的疾病活动性。比较不同严重程度UC患者之间PNI、中性粒细胞–淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)、血小板–淋巴细胞比值(platelet to lymphocyte ratio, PLR)、淋巴细胞–单核细胞比值(lymphocyte to monocyte ratio, LMR)、全身免疫炎症指数(systemic immune-inflammation index, SII)的差异,并进行上述指标分别与Mayo评分的相关性分析,应用受试者工作特征(receiver operating characteristic, ROC)曲线评估上述指标对UC活动的预测价值。结果:UC不同严重程度分组之间的PNI存在差异(P P Objective: To investigate the correlation between the Prognostic Nutritional Index (PNI) and disease activity in patients with Ulcerative Colitis (UC). Methods: A retrospective analysis was conducted on 117 patients who were first diagnosed with UC at Hebei General Hospital between September 2016 and May 2024. Data collected included patient demographics, clinical manifestations, laboratory tests, and endoscopic findings. Disease activity was assessed using the modified Mayo score. The Prognostic Nutritional Index (PNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and systemic immune inflammation index (SII) were compared across different severities of UC. Correlations between these biomarkers and Mayo scores were evaluated, and receiver operating characteristic (ROC) curves were generated to assess the predictive value of these indices for UC activity. Results: The differences in PNI across groups with varying disease severities were statistically significant (P P < 0.001). ROC
目的探讨免疫球蛋白A(IgA)肾病患者脂肪酸结合蛋白1(FABP1)和脂肪酸结合蛋白4(FABP4)水平与疾病活动性的相关性。方法选取2018年3月至2021年9月该院收治的IgA肾病患者240例作为观察组,另选取同期在该院体检健康的志愿者240例作为对照组。对比2组研究对象的收缩压、舒张压、24 h尿蛋白定量(24 h UTP)、肾小球滤过率(eGFR)和血肌酐(Scr)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)和血浆清蛋白(ALB)、FABP1、FABP4、IgA和补体C3(C3)水平。采用Pearson相关分析观察组血清FABP1、FABP4水平与IgA、C3、Scr、ALB和收缩压、舒张压、24 h UTP、eGFR、TC、TG、HDL-C的相关性;采用多因素Logistic回归分析影响IgA肾病患者疾病活动性的因素。结果观察组血清FABP4、IgA、C3、TC、TG和Scr水平以及收缩压、舒张压、24 h UTP显著高于对照组,而FABP1、eGFR、ALB和HDL-C水平显著低于对照组,差异均有统计学意义(P<0.05)。依据肾内活动性指数得分将观察组患者分为高分组(得分≥7分)174例和低分组(得分<7分)66例;与低分组相比,高分组血清FABP4、IgA和C3水平明显升高,FABP1、ALB水平和eGFR明显降低,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,IgA肾病患者血清FABP1水平均与IgA、C3、Scr水平及收缩压、舒张压、24 h UTP、TC和TG呈负相关(P<0.05),与eGFR、HDL-C和ALB水平呈正相关(P<0.05);血清FABP4水平均与IgA、C3、Scr水平和收缩压、舒张压、24 h UTP、TC和TG呈正相关(P<0.05),与eGFR、HDL-C和ALB水平呈负相关(P<0.05)。多因素Logistic回归分析结果显示,血清FABP4、IgA、C3水平升高是影响IgA肾病患者疾病活动性的危险因素(P<0.05),血清FABP1和ALB水平升高及eGFR增大是影响IgA肾病患者疾病活动性的保护因素(P<0.05)。结论IgA肾病患者血清FABP1水平降低,FABP4水平升高,二者与IgA肾病患者疾病活动性关系密切�