中空介孔二氧化硅纳米粒子(HMSNs)兼具中空和介孔的双重优点,具有较大的比表面积和空腔体积,形貌尺寸容易控制,且原材料丰富、价格低廉、制备简单、生物相容性好、易于化学修饰等众多优点使其成为良好的载体材料应用于催化、生物医药等方方面面,特别是在药物递送方面显示出良好的应用前景。本文综述了HMSNs的制备方法,强调了HMSNs在药物递送、多模态生物成像、疾病治疗、生物检测和组织工程等领域的广阔前景,旨在为HMSNs在未来的研究方向和实际应用提供参考。Hollow mesoporous silica nanoparticles (HMSNs) have the advantages of both hollow and mesoporous. Large specific surface area and cavity volume, easy control of morphology and size, rich raw materials, low price, simple preparation, good biocompatibility, and easy chemical modification make HMSNs a good carrier material for catalysis, biomedicine and other aspects, especially in drug delivery. This paper reviews the preparation methods of HMSNs, and emphasizes the broad prospects of HMSNs in the fields of drug delivery, multimodal biological imaging, disease treatment, biological detection and tissue engineering, in order to provide reference for the future research direction and practical application of HMSNs.
