目的:探讨并优化帕罗西汀血药浓度监测中的样品前处理方法,旨在通过引入瓶内处理技术和自动化样品前处理系统,实现快速、高效的前处理流程,提高监测效率与准确性。方法:综述了两种关键的优化策略:一是采用特制瓶内置过滤膜的瓶内处理技术,直接在单一瓶内完成样品分离与杂质去除;二是引入自动化样品前处理系统,如固相萃取自动化平台和在线样品处理系统,通过预设程序自动化完成样品提取、净化、浓缩等步骤。结果:这些优化方法显著缩短了样品前处理时间,平均处理时间从数小时缩短至数分钟至半小时内,提高了监测效率。同时,确保了分析结果的准确性和一致性,减少了人为操作带来的误差。此外,自动化系统的应用降低了人力成本,满足了高通量监测的需求。结论:通过引入瓶内处理技术和自动化样品前处理系统,帕罗西汀血药浓度监测的样品前处理过程实现了快速与高效。这些优化策略不仅提升了监测效率,还保证了分析结果的准确性,为临床用药指导和个体化治疗提供了有力支持。Objective: To explore and optimize the sample pre-treatment method in Paroxetine blood drug concentration monitoring. It aims to achieve a fast and efficient pre-processing process by introducing in-bottle treatment technology and automation sample processing systems to improve monitoring efficiency and accuracy. Methods: Two key optimization strategies are summarized: First, the in-bottle processing technology of the special bottle built-in filter film is used to complete the sample separation and impurity removal directly in a single bottle;And second, the automated sample pre-treatment systems are introduced, such as an automated platform for solid-phase extraction and an online sample processing system, to automatically complete the sample extraction, purification, concentration and other steps through the pre-set program. Result: These optimizati
