光动力疗法(PDT)是一种保守性治疗,光敏剂(PS)在特定波长的可见光照射下发生光化学反应,产生ROS,杀伤病变细胞从而达到治疗效果,具有多项优点,如难引发耐药性、高度的选择性、低毒性、微创性等,其最受广泛关注的在临床治疗的应用方面,集中于抗恶性肿瘤和多种皮肤黏膜疾病方向。PDT作为一种新型微创治疗方法,对于口腔多种微生物引起的感染拥有确切的治疗效果,且能解决口腔疾病治疗中常规物理手段会产生的一些缺陷,如难以彻底清除深部致病微生物、会引起较大创伤,影响生活质量及治疗过程复杂等难点,为口腔疾病治疗提供了新方向。口腔念珠菌病是一种口腔黏膜常见感染,是由以白色念珠菌为主的念珠菌属感染引起的口腔黏膜疾病,近年来随着抗真菌药物的广泛使用,其引发的耐药问题使临床治疗面临着严峻的挑战。Photodynamic therapy (PDT) is a conservative treatment in which photosensitizers (PS) under the irradiation of visible light at specific wavelengths undergo photochemical reactions, generate ROS, and kill diseased cells to achieve therapeutic effects, which has a number of advantages, such as difficulty in triggering drug resistance, highly selective, low toxicity, and minimally invasive, etc., and has received the most attention in the application of clinical treatment, focusing on the direction of the anti-malignant tumors and various skin and mucous membrane diseases. As a new minimally invasive therapeutic method, PDT has a definite therapeutic effect on infections caused by a variety of microorganisms in the oral cavity, and it can solve some of the defects of conventional physical means in the treatment of oral diseases, such as difficulty in completely removing deep-seated disease-causing microorganisms, causing large trauma, affecting the quality of life, and the complexity of the therapeutic process, thus providing a new direction for the treatment of oral diseas
