创伤性脑损伤(Traumatic Brain Injury, TBI)是指外力对大脑造成的损伤,由直接创伤因素以及间接创伤因素构成,直接创伤是以车祸、摔倒等外伤为主所导致,而间接创伤因素则是以运动、娱乐等造成大脑反复的变速运动所导致。TBI是我国创伤主要的致残、致死原因之一,尤其是以青、中年男性以及儿童为主的群体。TBI后,纤维蛋白溶解的亢进以及血小板功能的异常等过程,都将导致凝血功能发生紊乱,凝血功能紊乱不只是出血时间的延长和出血增多的低凝血功能障碍,还包含有静脉血栓形成风险增大的高凝血功能障碍。由于TBI引起的继发性脑损伤机制的复杂性以及高、低凝血功能障碍的矛盾性,都使得临床医师对患者治疗的方案及时机难以统一,因此本文旨在将TBI继发性凝血病的发生机制、检测方式和治疗进行综述,为临床治疗方法提供参考并改善患者预后。Traumatic Brain Injury (TBI) refers to the injury to the brain caused by external forces, which is composed of direct traumatic factors and indirect trauma factors. Direct traumatic factors are mainly caused by traumatic injuries such as car accidents and falls, while indirect trauma factors are caused by repeated variable speed movements of the brain caused by sports and entertainment. TBI is one of the main causes of disability and death in China, especially among young and middle-aged men and children. After TBI, hyperfibrinolysis and abnormal platelet function will lead to coagulation disorders, which are not only hypocoagulant dysfunction due to prolonged bleeding time and increased bleeding, but also hypercoagulant dysfunction with increased risk of venous thrombosis. Due to the complexity of the mechanism of secondary brain injury caused by TBI and the contradiction between high and low coagulation dysfunction, it is difficult for clinicians to unify the treatment plan and timing of patients, so this article aims to review the mechanism,
